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 Table of Contents  
ORIGINAL ARTICLE
Year : 2018  |  Volume : 2  |  Issue : 2  |  Page : 57-61

Glycosylated hemoglobin level changes following total knee arthroplasty in Type II diabetic patients: A retrospective cohort study


1 Department of Orthopedic, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
2 King Abdullah International Medical Research Center, Riyadh, Saudi Arabia

Date of Submission02-Jan-2018
Date of Decision25-Jan-2018
Date of Acceptance17-Mar-2018
Date of Web Publication09-May-2018

Correspondence Address:
Dr. Husam AlTahan
College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Al Hars Al Watani, Ar Rimayah, Riyadh - 14611
Saudi Arabia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jmsr.jmsr_1_18

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  Abstract 

Objectives: Total knee arthroplasty (TKA) has dramatically improved the quality of life of patients with end-stage arthritis, improving both their physical activity and functioning level. There are sufficient data illustrating the postoperative complications of patients with diabetes undergoing TKA. However, no satisfactory data exist illustrating the relationship of TKA on the glycosylated hemoglobin (HbA1c) levels in patients with type II diabetes postoperatively, which is the aim of this study. Methods: This retrospective cohort chart review study was conducted in King Abdulaziz Medical City, Riyadh, Saudi Arabia, where 308 individuals were included after applying the inclusion/exclusion criteria. The primary outcome was to establish if any association exists between type II diabetic patients and postoperative drop in HbA1c levels compared with nondiabetic patients. Results: The overall mean age was 65.5 years, and 67% of the total sample were patients with diabetes. Furthermore, 76% of the whole sample underwent unilateral knee surgery. The overall mean for pre- and post-HbA1c were 7.08 and 7.04, respectively. Conclusions: In our sample, there were more diabetic patients needing TKA than nondiabetic. It was also noticed that diabetic patients have a higher chance of undergoing bilateral TKA than unilateral when compared to nondiabetic patients, with both results being statistically significant. In addition, postoperative HbA1c level was significantly reduced in diabetic patients who underwent bilateral TKA when compared to diabetic patients who underwent unilateral TKA.

Keywords: Diabetes mellitus type II, glycosylated hemoglobin, hemoglobin A1c, Saudi Arabia, total knee arthroplasty


How to cite this article:
AlTurki A, AlTawayjri I, AlTahan H, Khan A, AlMalki M. Glycosylated hemoglobin level changes following total knee arthroplasty in Type II diabetic patients: A retrospective cohort study. J Musculoskelet Surg Res 2018;2:57-61

How to cite this URL:
AlTurki A, AlTawayjri I, AlTahan H, Khan A, AlMalki M. Glycosylated hemoglobin level changes following total knee arthroplasty in Type II diabetic patients: A retrospective cohort study. J Musculoskelet Surg Res [serial online] 2018 [cited 2018 May 20];2:57-61. Available from: http://www.journalmsr.com/text.asp?2018/2/2/57/232148


  Introduction Top


Since its introduction in the early 1970's, knee arthroplasty has dramatically improved the quality of life of patients suffering from end-stage arthritis, it has also been shown to be one of the most cost-effective procedures in modern medicine.[1] In addition, it is associated with an increase in both the physical activity and functioning level of patients, which were measured subjectively by patients' report and objectively by an increase in the knee society score and function score.[2] In the United States, >700,000 knee arthroplasty surgeries have been performed in 2012 and > 75,000 in the United Kingdom. These numbers have been increasing every year in developed countries.[3],[4],[5] The vast majority of total knee arthroplasty (TKA) procedures is performed for osteoarthritis (OA), which is the most common form of arthritis.[6] Due to the high prevalence of OA in older age groups, this procedure is frequently done for people whom are older than 65 years old.[7] Because of this rise in this particular population, they usually present with other comorbidities, diabetes mellitus (DM) in particular. OA and DM have been linked to aging and currently about 50% of type II diabetic patients are over 60 years of age.[8] Moreover, the estimated prevalence of DM in patients who undergo TKA and total hip arthroplasty (THA) in the United States is >8%.[9] Sufficient data exist to illustrate that diabetic patients undergoing TKA have shown significant increases in common surgical and systemic complications in addition to mortality during the initial hospital stay.[9],[10],[11] Such data have shown that diabetic patients undergoing total joint arthroplasty have a higher incidence of infection than patients without diabetes in addition to having a significantly increased risk of pneumonia, stroke after primary arthroplasty. Moreover, previous studies have reported higher rates of infection and wound complications in patients with DM undergoing TKA compared with patients without DM.[12] On the other hand, there are no satisfactory data illustrating the effect of TKA on blood glucose levels in the diabetic population postoperatively.[13]

The main aim of this study was to investigate the relationship between TKA and glycosylated hemoglobin (HbA1c) level in the diabetic population. It is hypothesized that patients undergoing joint arthroplasty will become more active and experience lower HbA1c levels.


  Materials and Methods Top


Study design, setting, and subjects

This retrospective cohort chart review study was carried out at the National Guard Health Affairs, Riyadh (Saudi Arabia). The inclusion and exclusion criteria are as follow:

Inclusion criteria

Patients aged 18 years or above and underwent a primary TKA for OA with a diagnosis of type II DM on dietary, oral, or insulin treatment. Total eligible individuals estimated to reach 500 patients since 2006 in our facility.

Exclusion criteria

  1. Type 1 diabetes
  2. Patients with other chronic diseases such as congestive heart failure, chronic liver disease, renal failure, and liver failure
  3. Patients undergoing Revision TKA.


The participants who had undergone TKA were identified using chart review from electronic medical records, and only the first primary replacement was the index surgery. Collected information were included demographics and all inpatient and outpatient diagnoses in addition to HbA1c laboratory results.

Total included eligible participants were 308 after applying the exclusion criteria.

Outcome, exposure, and potential confounder variables

Preoperative HbA1c indicates levels before surgery within 5–7 days, and postoperative levels were taken 6 months after the surgery.

Based on the literature review and surgeons input, the potential confounders such as age and gender were adjusted for.

Biases and sample size

Appropriate statistical methods were used to take into account the correlation of observations (due to bilateral TKA in a patient, simultaneously or sequentially). The estimated sample size was 350 with expected drop rate of 10%. It was based on a paired t-test using 10% difference in their standard deviation (SD) for preoperative and postoperative HbA1c level after surgery and considering a minimally clinically significant result to lower the pre-TKA level by 1%.

Statistical analyses

Descriptive statistics for demographic and clinical characteristics were measured as mean or median with SDs for continuous variables and as count and percentages for categorical variables. The preoperative and postoperative HbA1c levels were estimated using Pearson correlation. Paired t-test was used for preoperative and postoperative observations to see the effect of HbA1c measurements. Chi-square or Fisher's exact test was used to compare categorical variables between diabetic and nondiabetic patients. The general linear model, generalized estimation equation, and MIXED model statistical methods were applied to assess the effect of HbA1c levels for the covariates such as age, gender, DM, OA, and TKA. P < 0.05 was considered statistically significant. The statistical software packages: Statistical Analysis software (SAS) version 94 was used for data analysis (SAS institute, North Carolina, United States) was used for data analysis.

Ethical considerations

The study was approved by the ethics committee of the Internal Review Board of the King Abdullah International Medical Research Centre, Riyadh, Saudi Arabia.


  Results Top


Demographic and clinical characteristics

The overall mean age (mean + SD) was 65.5 ± 8.8 years. The female and males were distributed as 77% and 23%, whereas the diabetic and nondiabetic participants were distributed as 67% and 33%, respectively. Bilateral and unilateral knee surgeries were distributed as 24% and 76%, respectively. The overall mean preoperative and postoperative HbA1c levels were 7.08 ± 1.51 and 7.04 ± 1.52, respectively. When compared between diabetic and nondiabetic participants, the pre-and post-operative HbA1c levels showed a statistically significant difference. The overall nondiabetic versus diabetic, demographic, and clinical characteristics are presented in [Table 1].
Table 1: Basic demographics and clinical characteristics

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Univariate and multivariate association of diabetes after total knee arthroplasty

The correlation between pre-and post-operative HbA1c level was 77%, which is statistically significant (P< 0.05, 95% confidence interval). Scatter diagram for pre-and post-operative HbA1c levels are shown in [Figure 1], and the correlation between pre-and post-operative HbA1c level is 68%, which is also statistically significant (P< 0.05). [Figure 2] shows the regression line for pre-and post-operative HbA1c level at different age categories. The slope line in red shows that older participants have a steeper slope than other age categories, and slope line in blue for other age categories are overlapped, whereas the box plot also shows that postoperative HbA1c level is higher for older population. Moreover, [Figure 3] shows HbA1c levels between nondiabetic versus diabetic participants. It shows that HbA1c levels at different age groups get elevated among diabetic participants, whereas it remains almost consistent among nondiabetic participants. Similarly, the mean slope line is higher for diabetic participants. Furthermore, there was no evidence of an association between gender and diabetes (P = 0.8056, odds ratio of 1.0669). The variable was regrouped as: OA versus others, and this variable versus diabetic and nondiabetic participants shows that there is a statistically significant association between these two variables using (P< 0.05). Moreover, paired t-test was performed and showed no statistically significant difference between pre-and post-operative HbA1c levels (t = 0.33, P = 0.7403). Furthermore, the analysis of covariance was modeled for the pre-and post-operative HbA1c along with the covariates such as Gender and TKA, which was significant overall (P< 0.05). A group test statistic for the equality of means is reported for both equal and unequal variances. The equality of variances test indicates a significant difference between unilateral and bilateral surgery side (F = 2.15 and P < 0.05).
Figure 1: Correlation is 77% with 95% prediction ellipse between pre-operative and post-operative glycosylated hemoglobin levels shown in left, and right figure scatter plot is shown

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Figure 2: The slope is steeper (regression line) for participants above 60-year-old as well as higher values after postoperative glycosylated hemoglobin levels

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Figure 3: The glycosylated hemoglobin levels are constant at different age groups among nondiabetic participants have lower slope shown in red color

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  Discussion Top


In the present study, we compared multiple variables in diabetic and nondiabetic patients. Our results could not illustrate any association between gender and DM which is consistent with a previous systematic review.[17] There is no statistically significant difference between diabetic and nondiabetic participants in relation to having unilateral or bilateral TKA. However, our study shows that diabetic participants have higher chances of undergoing TKA when compared to nondiabetic participants. In addition, diabetic patients have a higher chance of undergoing bilateral TKA than unilateral when compared to nondiabetic patients, with both results being statistically significant. Additionally, the level of HbA1c postoperatively was significantly reduced in diabetic patients who underwent bilateral TKA when compared to diabetic patients who underwent unilateral TKA as illustrated in the figures earlier. This significant reduction in postoperative HbA1c levels in bilateral TKA is probably attributed to the greater degree of improvement in clinical outcomes for Oxford Knee Score, Knee Society Score-Functional, and Objective scores and short form 36 (SF-36) as compared to unilateral TKA, as demonstrated by Lim JB.[14]

OA was the leading cause of TKA in our study population. It was also highly prevalent amongst diabetic participants compared to nondiabetic participants, which is consistent with a previous local study.[15] Louati et al. have also illustrated in a systematic review that OA is highly frequent amongst diabetic patients, indicating a possible association between the two diseases, while another prospective study identified a significant association between OA and DM.[16],[17] When it comes to HbA1c levels in diabetic patients, our study shows no significant difference between the mean pre-and post-operative levels (7.74 and 7.71, respectively). Multiple factors could be hindering our proposed theory, including the presence of other diseases such as metabolic syndrome, which has shown to be associated with a decrease in physical activity levels and cardiorespiratory fitness.[18] Another factor is whether patients had undergone proper postoperative physiotherapy treatment which could not be accurately measured in our study, as part of the treatment includes home physiotherapy which is not easily assessed and measured. Although a prospective study showed that diabetes by itself is associated with poor functional outcome, Artz et al. illustrated that proper physiotherapy treatment post-TKA can lead to improvement in the physical function of patients in the first 3–4 months and can extend up to 6 months.[3],[19]

There are multiple limitations to our study. First, there are other factors, which haven't been measured that could possibly affect the results, including the quality and type of therapy (insulin vs. no insulin), postoperative rehabilitation and physiotherapy, and the presence of metabolic syndrome. Second, patients body mass index levels were not obtained pre-and post-operatively to observe any change, which could have been translated to a likely increase in physical performance.


  Conclusions Top


In our sample, there were more diabetic patients needing TKA than nondiabetic. It was also noticed that diabetic patients have a higher chance of undergoing bilateral TKA than unilateral when compared to nondiabetic patients, with both results being statistically significant. Additionally, postoperative HbA1c level was significantly reduced in diabetic patients who underwent bilateral TKA when compared to diabetic patients who underwent unilateral TKA.

We highly recommend further extensive prospective research looking at the effect of TKA on postoperative HbA1c in diabetic patients while putting into account other variables and cofounding factors mentioned in our limitations.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

Authors contributions

AA contributed in conducting the research, choosing the study design and providing research materials. IA conducted the research, collected the data in addition to analyzing it and edited the manuscript. MA collected the data, analyzed it, and contributed in manuscript writing and editing. AK contributed in choosing the study design, analyzing data and editing the manuscript. HA contributed in analyzing the data and editing the manuscript. All authors have critically reviewed and approved the final draft and are responsible for the content and similarity index of the manuscript.

 
  References Top

1.
Ranawat CS. History of total knee replacement. J South Orthop Assoc 2002;11:218-26.  Back to cited text no. 1
[PUBMED]    
2.
Lützner C, Beyer F, Kirschner S, Lützner J. How much improvement in patient activity can be expected after TKA? Orthopedics 2016;39:S18-23.  Back to cited text no. 2
    
3.
Singh JA, Lewallen DG. Diabetes: A risk factor for poor functional outcome after total knee arthroplasty. PLoS One 2013;8:e78991.  Back to cited text no. 3
[PUBMED]    
4.
Culliford DJ, Maskell J, Beard DJ, Murray DW, Price AJ, Arden NK,et al. Temporal trends in hip and knee replacement in the united kingdom: 1991 to 2006. J Bone Joint Surg Br 2010;92:130-5.  Back to cited text no. 4
    
5.
Carr AJ, Robertsson O, Graves S, Price AJ, Arden NK, Judge A,et al. Knee replacement. Lancet 2012;379:1331-40.  Back to cited text no. 5
[PUBMED]    
6.
Busija L, Bridgett L, Williams SR, Osborne RH, Buchbinder R, March L,et al. Osteoarthritis. Best Pract Res Clin Rheumatol 2010;24:757-68.  Back to cited text no. 6
[PUBMED]    
7.
Gillespie GN, Porteous AJ. Obesity and knee arthroplasty. Knee 2007;14:81-6.  Back to cited text no. 7
[PUBMED]    
8.
Cowie CC, Rust KF, Ford ES, Eberhardt MS, Byrd-Holt DD, Li C,et al. Full accounting of diabetes and pre-diabetes in the U.S. Population in 1988-1994 and 2005-2006. Diabetes Care 2009;32:287-94.  Back to cited text no. 8
    
9.
Arthroplasty2 Bolognesi MP, Marchant MH Jr., Viens NA, Cook C, Pietrobon R, Vail TP,et al. The impact of diabetes on perioperative patient outcomes after total hip and total knee arthroplasty in the united states. J Arthroplasty 2008;23:92-8.  Back to cited text no. 9
    
10.
Singh JA, Vessely MB, Harmsen WS, Schleck CD, Melton LJ 3rd, Kurland RL,et al. A population-based study of trends in the use of total hip and total knee arthroplasty, 1969-2008. Mayo Clin Proc 2010;85:898-904.  Back to cited text no. 10
[PUBMED]    
11.
Iorio R, Williams KM, Marcantonio AJ, Specht LM, Tilzey JF, Healy WL,et al. Diabetes mellitus, hemoglobin A1C, and the incidence of total joint arthroplasty infection. J Arthroplasty 2012;27:726-90.  Back to cited text no. 11
    
12.
Hwang JS, Kim SJ, Bamne AB, Na YG, Kim TK. Do glycemic markers predict occurrence of complications after total knee arthroplasty in patients with diabetes? Clin Orthop Relat Res 2015;473:1726-31.  Back to cited text no. 12
[PUBMED]    
13.
Vaidya SV, Arora A, Mathesul AA. Effect of total knee arthroplasty on type II diabetes mellitus and hypertension: A prospective study. Indian J Orthop 2013;47:72-6.  Back to cited text no. 13
[PUBMED]  [Full text]  
14.
Hilawe EH, Yatsuya H, Kawaguchi L, Aoyama A. Differences by sex in the prevalence of diabetes mellitus, impaired fasting glycaemia and impaired glucose tolerance in sub-saharan africa: A systematic review and meta-analysis. Bull World Health Organ 2013;91:671-82D.  Back to cited text no. 14
[PUBMED]    
15.
Turki AS, Dakhil YA, Turki AA, Ferwana MS. Total knee arthroplasty: Effect of obesity and other patients' characteristics on operative duration and outcome. World J Orthop 2015;6:284-9.  Back to cited text no. 15
[PUBMED]    
16.
Louati K, Vidal C, Berenbaum F, Sellam J. Association between diabetes mellitus and osteoarthritis: Systematic literature review and meta-analysis. RMD Open 2015;1:e000077.  Back to cited text no. 16
[PUBMED]    
17.
Rahman MM, Cibere J, Anis AH, Goldsmith CH, Kopec JA. Risk of type 2 diabetes among osteoarthritis patients in a prospective longitudinal study. Int J Rheumatol 2014;2014:620920.  Back to cited text no. 17
[PUBMED]    
18.
Rennie KL, McCarthy N, Yazdgerdi S, Marmot M, Brunner E. Association of the metabolic syndrome with both vigorous and moderate physical activity. Int J Epidemiol 2003;32:600-6.  Back to cited text no. 18
[PUBMED]    
19.
Artz N, Elvers KT, Lowe CM, Sackley C, Jepson P, Beswick AD,et al. Effectiveness of physiotherapy exercise following total knee replacement: Systematic review and meta-analysis. BMC Musculoskelet Disord 2015;16:15.  Back to cited text no. 19
    


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