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CASE REPORT
Year : 2020  |  Volume : 4  |  Issue : 1  |  Page : 56-60

Multifocal rosai–dorfman disease


1 Department of Surgery, King Abdalaziz Medical City, King Abdalleah Research Center, King Saud Bin Abdalaziz University for Health Science, Riyadh, Saudi Arabia
2 College of Medicine, University of Hail, Hail, Saudi Arabia
3 Department of Orthopedics, AlRazi Hospital, Kuwait Institution for Medical Specializations, Kuwait City, Kuwait, Saudi Arabia
4 Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, King Abdullah International Medical Research Center, College of Medicine, King Saud bin Abdulaziz for Health Sciences, Riyadh, Saudi Arabia

Correspondence Address:
Dr. Wazzan S Aljuhani
Department of Surgery, King Abdalaziz Medical City, King Abdalleah Research Center, King Saud Bin Abdalaziz University for Health Science, Riyadh
Saudi Arabia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jmsr.jmsr_95_19

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Rosai–Dorfman disease (RDD) is an uncommon proliferative histiocytic disorder whose etiology remains unknown. It is equally identified by the nomenclature sinus histiocytosis with massive lymphadenopathy. The major causes appear to be autoimmune dysregulation or proliferation of the histiocytes secondary to infection. The current diagnosis of this disorder is based on cytological and histological characteristics, with positive CD68 and S100 markers, and emperipolesis as the key diagnostic factor. We present the case of a 37-year-old man with multiple soft tissue masses in the left thigh, scalp, and back whose histological features were consistent with soft tissue RDD, which is an unusual presentation of this relatively rare disease.


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